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Highlights • A model to assess drug interaction effects on drug induced respiratory depression.• Plasma oxycodone level AUC was 113 % higher when the two drugs were co-administered.• Diazepam showed… Click to show full abstract
Highlights • A model to assess drug interaction effects on drug induced respiratory depression.• Plasma oxycodone level AUC was 113 % higher when the two drugs were co-administered.• Diazepam showed synergistic effects on respiratory depression when given with oxycodone.• Combination of diazepam and oxycodone decreased resting arterial pO2 AUC by 17 %.• Combination of diazepam and oxycodone increased resting arterial pCO2 AUC by 25 %.
Keywords:
induced respiratory;
drug induced;
drug;
model;
respiratory depression
Journal Title: Toxicology Reports
Year Published: 2020
Link to full text (if available)
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Journal Title: Toxicology Reports
Year Published: 2020
Link to full text (if available)
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recommendations!