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A critical assessment of the estrogenic potency of benzyl salicylate

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Highlights • Benzyl salicylate (BS) is on priority lists for evaluation of estrogenic effects.• New data in both MCF7 (E-screen) and luciferase transactivation assays.• Potency of BS is 21′000′000-fold lower… Click to show full abstract

Highlights • Benzyl salicylate (BS) is on priority lists for evaluation of estrogenic effects.• New data in both MCF7 (E-screen) and luciferase transactivation assays.• Potency of BS is 21′000′000-fold lower than estradiol in transactivation assay.• Potency of BS is 36′000′000-fold lower than estradiol in E-screen.• Potency is > 1000-fold below human relevant potency threshold.

Keywords: benzyl salicylate; potency; estrogenic potency; potency benzyl; assessment estrogenic; critical assessment

Journal Title: Toxicology Reports
Year Published: 2021

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