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NAD+ Cleavage: TIR Domain-Containing Resistance Proteins in Action.

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Plant resistance proteins play a key role in detecting pathogen infection and activating plant defense. Two recent papers by Horsefield et al. and Wan et al. revealed that the TIR domain in resistance… Click to show full abstract

Plant resistance proteins play a key role in detecting pathogen infection and activating plant defense. Two recent papers by Horsefield et al. and Wan et al. revealed that the TIR domain in resistance (R) proteins functions as an NAD+-cleaving enzyme. This enzymatic activity is induced by pathogen recognition and is indispensable for the R protein-dependent cell death response.

Keywords: tir domain; resistance proteins; resistance; nad cleavage

Journal Title: Trends in plant science
Year Published: 2019

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