LAUSR

Highlights • Differential expression analysis showed a total of 304 differentially expressed genes, which were mainly related to proteoglycans in cancer, the PI3K/Akt signaling pathway, and the TGF-beta signaling pathway.• The survival-related linear risk assessment model consisting of eight genes (FERMT2, ITGA5, ITGB1, MCAM, CEMIP, HGF, TGFBR1, F2RL2) was constructed. The survival rates of high-risk patients were significantly lower than that of the low-risk group, and the 3-, 5-, and 10-year AUCs were satisfactory.• BMP2, BMPR2, and GREM1 were differentially expressed in both data sets of breast cancer bone metastasis.• In GSE20685 and GSE45255, significant differences in immune infiltration patterns were found between high- and low-risk groups.• BMP-2 may regulate the immune infiltration process in breast cancer tissues through the PI3K/Akt signaling pathway.