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HPV DNA/RNA detection in various oral and oropharyngeal biomaterials identifies active HPV infections also in non-neoplastic tonsils

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Highlights • Fist study analysing tissue, brushes and sputum for all patients also for viral mRNA.• HPV detection performed in brushes/sputum inconsistently reflect tissue HPV status.• In terms of virus… Click to show full abstract

Highlights • Fist study analysing tissue, brushes and sputum for all patients also for viral mRNA.• HPV detection performed in brushes/sputum inconsistently reflect tissue HPV status.• In terms of virus activity, p16 seems insufficient to predict tissue HPV status.• E6-mRNA analysis detects active HPV infection in non-neoplastic tonsillar tissues.• Data gives rise to the question whether tonsillectomy might prevent TSCC.

Keywords: detection; hpv dna; hpv; dna rna; active hpv; non neoplastic

Journal Title: Translational Oncology
Year Published: 2020

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