LAUSR

Highlights • We comprehensively analyzed both BRAF mutation status and MLH1 promoter methylation status in MLH1-deficient patients from a large consecutive CRC cohort, which may help to modify strategy of LS screening for Chinese MLH1-deficient CRCs.• To our knowledge, this study is the first to systematically evaluate the characteristic of family history associated with LS patients harboring somatic MLH1 promoter methylation in Chinese population.• Our results contribute to a better understanding of the role of these two methods in LS screening among CRCs with a lower incidence rate of BRAF V600E mutation in some races.