"IRF2 regulates cellular survival and Lenvatinib-sensitivity of hepatocellular carcinoma (HCC) through regulating β-catenin"

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Highlights • IRF2 and β-catenin are highly expressed in HCC tissues.• IRF2 upregulation of β-catenin promotes HCC cell proliferation.• IRF2 enhances lenvatinib resistance in HCC cells. Click to show full abstract

Highlights • IRF2 and β-catenin are highly expressed in HCC tissues.• IRF2 upregulation of β-catenin promotes HCC cell proliferation.• IRF2 enhances lenvatinib resistance in HCC cells.

Keywords: hcc; cellular survival; catenin; irf2 regulates; regulates cellular

Journal Title: Translational Oncology
Year Published: 2021

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