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Highlights • High-risk HPV infection is less frequently detected in HIV-positive non-metastatic ASCC compared with HIV-negative cases.• Mutational profile identified in the non-metastatic ASCC cohort revealed expected similarities with metastatic… Click to show full abstract
Highlights • High-risk HPV infection is less frequently detected in HIV-positive non-metastatic ASCC compared with HIV-negative cases.• Mutational profile identified in the non-metastatic ASCC cohort revealed expected similarities with metastatic ASCC.• High PD-L1 expression levels are associated with high CD3 and CD8 TIL density, complete response to treatment, and good survival outcome of ASCC patients.• PD-L1 is a reliable predictive and prognostic biomarker that allows the stratification in low- vs. high-risk ASCC patients at their initial therapeutic approach.
Journal Title: Translational Oncology
Year Published: 2021
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