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Highlights • The recombinant Chinese measles virus vaccine strain rMV-Hu191 induced efficient infection and oncolytic effects in human CRC both in vitro and in vivo.• rMV-Hu191 induced the caspase-dependent apoptosis… Click to show full abstract
Highlights • The recombinant Chinese measles virus vaccine strain rMV-Hu191 induced efficient infection and oncolytic effects in human CRC both in vitro and in vivo.• rMV-Hu191 induced the caspase-dependent apoptosis and complete autophagy in CRC cells.• Autophagy served as a protective role in human CRC cells’ apoptosis induced by rMV-Hu191.• rMV-Hu191-induced autophagy and apoptosis were regulated by the PI3K/AKT signaling pathway in human CRC.
Keywords:
apoptosis;
rmv hu191;
hu191;
recombinant chinese;
chinese measles
Journal Title: Translational Oncology
Year Published: 2021
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Journal Title: Translational Oncology
Year Published: 2021
Link to full text (if available)
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recommendations!