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Highlights • Expression of activator protein-1 (AP-1) family is significantly elevated in triple-negative breast cancer (TNBC), compared with that in other breast cancer subtypes.• T-5224, an inhibitor of c-Fos/AP-1 resulted… Click to show full abstract
Highlights • Expression of activator protein-1 (AP-1) family is significantly elevated in triple-negative breast cancer (TNBC), compared with that in other breast cancer subtypes.• T-5224, an inhibitor of c-Fos/AP-1 resulted in increase of apoptosis and inhibition of proliferation, migration, and invasion of TNBC cells.• High OLFML2A level is associated with poor prognosis in TNBC patients that were identified from multiple clinical data sets on line.• AP1-overexpressing TNBC dependent on OLFML2A, and targeting both AP-1 and OLFML2A through T‐5224 may be a synergistic therapeutic strategy for this clinically challenging subset of breast cancer.
Journal Title: Translational Oncology
Year Published: 2021
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