Highlights • MMP3 is upregulated in colon cancers.• Tumor cell-associated MMP3 expression is important for tumor growth.• The cancer therapy by MMP3 inhibition is improved together with oncolytic virus.• Downregulation… Click to show full abstract
Highlights • MMP3 is upregulated in colon cancers.• Tumor cell-associated MMP3 expression is important for tumor growth.• The cancer therapy by MMP3 inhibition is improved together with oncolytic virus.• Downregulation of MMP3 reduces tumor cell invasion.• Erk1/2 and NF-κB signaling are changed by MMP3 downregulation.
Keywords:
oncolytic virus;
mmp3;
therapy;
targeting matrix;
tumor
Journal Title: Translational Oncology
Year Published: 2021
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Journal Title: Translational Oncology
Year Published: 2021
Link to full text (if available)
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recommendations!