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Highlights • Elevated expression of Wnt pathway associated factors in HPV-positive penile cancer cells.• lacking nuclear beta-catenin translocation indicated an actively abrogated Wnt signaling.• elevated expression of the Wnt antagonist… Click to show full abstract
Highlights • Elevated expression of Wnt pathway associated factors in HPV-positive penile cancer cells.• lacking nuclear beta-catenin translocation indicated an actively abrogated Wnt signaling.• elevated expression of the Wnt antagonist DKK1 in HPV-positive penile cancer cells.• DKK1-driven autocrine Wnt pathway inhibition in penile cancer cells.• DKK1+ penile cancers are with a higher frequency HPV+, less differentiated and grow more aggressively.
Keywords:
wnt;
penile;
cancer cells;
penile cancer;
positive penile
Journal Title: Translational Oncology
Year Published: 2021
Link to full text (if available)
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Journal Title: Translational Oncology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!