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Highlights • MV3-Exo inhibits CD4+ t cell immune function and induces M2-polarized macrophages.• TIM-3 is upregulated in MV3 cells-secreted exosomes.• TIM-3 inhibits CD4+ t cell immune function and induces M2-polarized… Click to show full abstract
Highlights • MV3-Exo inhibits CD4+ t cell immune function and induces M2-polarized macrophages.• TIM-3 is upregulated in MV3 cells-secreted exosomes.• TIM-3 inhibits CD4+ t cell immune function and induces M2-polarized macrophages.• TIM-3 shuttled by MV3-Exo promotes growth and metastasis of melanoma.• The study unveiled a protective target against metastasis of melanoma.
Keywords:
function induces;
immune function;
cd4 cell;
metastasis melanoma;
inhibits cd4;
cell immune
Journal Title: Translational Oncology
Year Published: 2022
Link to full text (if available)
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Journal Title: Translational Oncology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!