LAUSR

Highlights • Current risk prediction models use a variety of factors to identify women at risk of developing breast cancer.• Proteins circulating in blood represent an attractive but currently still underrepresented source of candidates serving as molecular risk factors.• Plasma samples from women participating in a prospective breast cancer cohort study were studied for proteomic risk factors related to a future breast cancer diagnosis.• Applying data-driven approaches on the levels of circulating proteins, women with future breast cancers and previous use of menopausal hormone therapy were identified.• Menopausal hormone therapy was found to alter components of the circulating proteomes even years after the treatment ended.