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Long non-coding RNA HNF1A-AS1 induces 5-FU resistance of gastric cancer through miR-30b-5p/EIF5A2 pathway

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Highlights • HNF1A-AS1 promotes 5-FU resistance in gastric cancer cells.• HNF1A-AS1 regulates EIF5A2 expression through sponging miR-30b-5p.• HNF1A-AS1 promotes EMT process and 5-FU resistance through miR-30b-5p/EIF5A2 pathway.• HNF1A-AS1 promotes 5-FU… Click to show full abstract

Highlights • HNF1A-AS1 promotes 5-FU resistance in gastric cancer cells.• HNF1A-AS1 regulates EIF5A2 expression through sponging miR-30b-5p.• HNF1A-AS1 promotes EMT process and 5-FU resistance through miR-30b-5p/EIF5A2 pathway.• HNF1A-AS1 promotes 5-FU resistance in gastric cancer in vivo.

Keywords: gastric cancer; mir 30b; resistance gastric; hnf1a as1

Journal Title: Translational Oncology
Year Published: 2022

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