Highlights • A novel pair of orthotopic PDX models of glioma bearing IDH1-R132H/R132C mutations.• New mutant IDH1i (SY-435) with standard therapy led to strong therapeutic efficacy.• H3K4/K9 methylation/mtDNA-encoded molecules mediate… Click to show full abstract
Highlights • A novel pair of orthotopic PDX models of glioma bearing IDH1-R132H/R132C mutations.• New mutant IDH1i (SY-435) with standard therapy led to strong therapeutic efficacy.• H3K4/K9 methylation/mtDNA-encoded molecules mediate anti-tumor activity of SYC-435.• Discovered MYO1F, CTC1 and BCL9 as novel genes that mediated SYC-435 resistance.
Keywords:
435 standard;
syc 435;
models glioma;
standard therapy;
anti tumor
Journal Title: Translational Oncology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Translational Oncology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!