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The expression of Slit2 and Robo1 increased during retinoic acid syndrome in acute promyelocytic leukemia and impacted differentiated cell migration

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Highlights • The upregulation of Robo1 and Slit2 was first found in APL patients.• The positive correlation between Robo1/Slit2 and retinoic acid syndrome was first demonstrated.• It was demonstrated for… Click to show full abstract

Highlights • The upregulation of Robo1 and Slit2 was first found in APL patients.• The positive correlation between Robo1/Slit2 and retinoic acid syndrome was first demonstrated.• It was demonstrated for the first time that Slit2 induces the migration of differentiated cells.• Slit2 did not inhibit il8-induced differentiated cell migration.

Keywords: acid syndrome; robo1; slit2; differentiated cell; migration; retinoic acid

Journal Title: Translational Oncology
Year Published: 2022

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