LAUSR

The incremental understanding of the anatomy and pathophysiology of aortic dissection over the past 250 years has predicated the modern endovascular treatments in use today. Since the early descriptions of aortic dissection, our knowledge of the predisposing factors and hemodynamic disturbances that lead to aortic dissection and overlapping syndromes, including intramural hematoma and penetrating atherosclerotic ulcer, has been fine-tuned, aided by more advanced ultrastructural histopathologic analysis and modern cross-sectional imaging techniques. However, several controversies and ambiguities of the pathophysiology and natural history of aortic dissection persist, leading to ongoing challenges in prevention, clinical diagnosis and treatment. In this review, we aim to describe the anatomy, pathology, and classification of aortic dissection and introduce the pathophysiologic basis for endovascular therapies.