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Tailoring the size of ultrasound responsive lipid-shelled nanodroplets by varying production parameters and environmental conditions

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Highlights • Increasing the volumetric concentration of PFP led to an increase in the size of lipid-coated PFP NDs.• Increasing sonication intensity and time led to a decrease in ND… Click to show full abstract

Highlights • Increasing the volumetric concentration of PFP led to an increase in the size of lipid-coated PFP NDs.• Increasing sonication intensity and time led to a decrease in ND size.• The ND coating layer can be labelled with lipophilic fluorophores without affecting the overall ND size.• NDs were stable at 4 °C for one week, and at 37 °C for 110 min.• Ultrasound (0.5 MHz, 2–4 MPa) caused vaporisation of NDs within a tissue-mimicking phantom.

Keywords: size ultrasound; tailoring size; lipid shelled; size; ultrasound responsive; responsive lipid

Journal Title: Ultrasonics Sonochemistry
Year Published: 2021

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