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Evolving Trends for Selected Treatments of T1a Renal Cell Carcinoma.

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OBJECTIVES To evaluate contemporary trends in the management of SRMs and how patient age has impacted practice patterns METHODS: Using the NCDB PUF from 2002-2015, we identified patients with T1a… Click to show full abstract

OBJECTIVES To evaluate contemporary trends in the management of SRMs and how patient age has impacted practice patterns METHODS: Using the NCDB PUF from 2002-2015, we identified patients with T1a renal masses. The initial treatment was categorized as radical nephrectomy (RN), partial nephrectomy (PN), ablation, or surveillance. A multinominal logistic regression model was used to identify significant factors impacting treatment. RESULTS We identified 75,691 patients for analysis. RN, PN, and ablation accounted for 28%, 52% and 12%, respectively, while 8% were managed with AS. In the past decade the likelihood of undergoing PN, ablation, or surveillance compared to RN has consistently increased, independent of age, sex, race, comorbidity, tumor size, or institution. As age increased, patients were independently less likely to undergo PN and more likely to be managed with ablation or AS. Compared to patients under 40 years of age, patients between 70-79 were far less likely to undergo PN (RR 0.58, p<0.01), and far more likely to undergo either ablation (RR 5.53, p<0.01) or AS (RR 3.7, p<0.01). CONCLUSIONS Trends in SRM management continue to evolve, with PN supplanting RN over the past decade as the predominant surgical treatment. Age significantly impacts treatment selection, particularly in older cohorts whom are much more likely to undergo ablation or AS. While the use of minimally invasive therapies has increased over the past decade, AS lags behind despite quality data supporting its use. When controlling for multiple clinical factors, PN, ablation and surveillance have consistently increased in utilization compared to RN.

Keywords: age; ablation; treatment; ablation surveillance; likely undergo; t1a renal

Journal Title: Urology
Year Published: 2019

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