Highlights • Rotavirus vaccines (RVs) have been recently introduced in low-income settings.• Accurate post-introduction monitoring of RV effectiveness is important.• The test-negative design (TND) is used to measure RV effectiveness.•… Click to show full abstract
Highlights • Rotavirus vaccines (RVs) have been recently introduced in low-income settings.• Accurate post-introduction monitoring of RV effectiveness is important.• The test-negative design (TND) is used to measure RV effectiveness.• The TND was evaluated using randomized trials of RV in sub-Saharan Africa and Asia.• The TND is an appropriate method to measure RV effectiveness in low-income settings.
               
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