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Highlights • VRC01 epitope focused structure-based immunogen design.• Gp120 outer-domain core was further stabilized by 375 tryptophan substitution.• Epitope specific antibodies were predominately induced through guinea pig immunizations. Click to show full abstract
Highlights • VRC01 epitope focused structure-based immunogen design.• Gp120 outer-domain core was further stabilized by 375 tryptophan substitution.• Epitope specific antibodies were predominately induced through guinea pig immunizations.
Keywords:
gp120;
domain core;
outer domain;
immunogen design
Journal Title: Vaccine
Year Published: 2017
Link to full text (if available)
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Journal Title: Vaccine
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!