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Safety and immunogenicity of a Vi-DT typhoid conjugate vaccine: Phase I trial in Healthy Filipino adults and children

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Highlights • Vi-DT is safe and well tolerated in participants aged 2–45 years.• Significantly higher immune responses post Vi-DT compared to Vi polysaccharide vaccine.• No further increase in GMT post second… Click to show full abstract

Highlights • Vi-DT is safe and well tolerated in participants aged 2–45 years.• Significantly higher immune responses post Vi-DT compared to Vi polysaccharide vaccine.• No further increase in GMT post second dose as compared to post first dose of Vi-DT.

Keywords: typhoid conjugate; conjugate vaccine; safety immunogenicity; immunogenicity typhoid; vaccine; vaccine phase

Journal Title: Vaccine
Year Published: 2018

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