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Protective efficacy of peptides from Plasmodium vivax circumsporozoite protein

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Highlights • Short repeat-region peptides from PvCSP on a VLP protect against malaria.• The AGDR tetramer from PvCSP VK210 can, on a VLP, also protect against malaria.• Full-length PvCSP is… Click to show full abstract

Highlights • Short repeat-region peptides from PvCSP on a VLP protect against malaria.• The AGDR tetramer from PvCSP VK210 can, on a VLP, also protect against malaria.• Full-length PvCSP is much less protective as a vaccine than truncated PvCSP.• Region I and II peptides confer no protection against malaria presented on a VLP.

Keywords: circumsporozoite protein; peptides plasmodium; protective efficacy; efficacy peptides; plasmodium vivax; vivax circumsporozoite

Journal Title: Vaccine
Year Published: 2020

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