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An important aspect of the CiPA (Comprehensive In Vitro Proarrhythmia Assay) proposal is the use of human stem cell-derived cardiomyocytes and the confirmation of their predictivity in drug safety assays.… Click to show full abstract
An important aspect of the CiPA (Comprehensive In Vitro Proarrhythmia Assay) proposal is the use of human stem cell-derived cardiomyocytes and the confirmation of their predictivity in drug safety assays. The benefits of this cell source are clear, drugs can be tested in vitro on human cardiomyocytes, with patient-specific genotypes if needed, and differentiation efficiencies are generally excellent, resulting in a virtually limitless supply of cardiomyocytes.
Keywords:
integrating dynamic;
clamping;
clamping automated;
dynamic clamping;
automated patch;
patch clamping
Journal Title: Journal of Pharmacological and Toxicological Methods
Year Published: 2018
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Journal Title: Journal of Pharmacological and Toxicological Methods
Year Published: 2018
Link to full text (if available)
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recommendations!