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Abstract In this work, we correlate Raman spectroscopy in vivo which is performed in healthy bone tibia, 3-month-old mice with osteoporotic bone, within two groups: OVX (ovariectomized) and sham (lumbar… Click to show full abstract
Abstract In this work, we correlate Raman spectroscopy in vivo which is performed in healthy bone tibia, 3-month-old mice with osteoporotic bone, within two groups: OVX (ovariectomized) and sham (lumbar access, no ovariectomy group control). Laser beam was applied directly in a punch of skin in the distal medial part of tibia. To access bone quality, we calculate mineral/matrix ratio, relative lipid and proteoglycan content as well as the crystallinity using normalized spectrum within the integrated area method. The variables obtained for bone quality were statistically verify by ANOVA and tested for normality, where differences were considered to be significant for P
Journal Title: Vibrational Spectroscopy
Year Published: 2018
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