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Highlights • Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo.• Intraperitoneal administration of tilorone leads to protection against intracranial lethal challenge of SFTSV.• The anti-SFTSV mechanism of… Click to show full abstract
Highlights • Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo.• Intraperitoneal administration of tilorone leads to protection against intracranial lethal challenge of SFTSV.• The anti-SFTSV mechanism of tilorone is through stimulation of host innate immunity.• Pre-treatment with tilorone can prevent mice from lethal SFTSV challenge.
Keywords:
vitro vivo;
confers robust;
tilorone confers;
tilorone;
vivo antiviral;
robust vitro
Journal Title: Virologica Sinica
Year Published: 2022
Link to full text (if available)
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Journal Title: Virologica Sinica
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!