LAUSR

OBJECTIVE Despite the increasing evidence of the association between breast cancer and meningioma in women, the relationship between these tumors remains improperly examined. In this study, we aim to identify the socio-demographic and clinicopathological features of women with breast cancer associated with a higher risk of developing a meningioma. METHODS The Surveillance, Epidemiology, and End Results database (18 registries) was used to identify women with breast cancer as their first neoplasm. The risk of subsequent meningioma was reported as the standardized incidence ratio (SIR) and was analyzed by socio-demographic and clinicopathological subgroups. Results are given as SIR [95% CI]. RESULTS A total of 564,516 women diagnosed with breast cancer between 2004-2016 were included for analysis. A 26% increased risk of meningioma development (SIR 1.26 [1.19-1.33]; P<0.05) was found in the cohort compared to the general population. Patients between ages 18-49 (SIR 2.16 [1.78-2.61]; P<0.05) and those with a more advanced tumor stage (Stage IV, SIR 2.39 [1.71-3.25]; P<0.05) were at a higher risk. Hormone receptor expression and treatment modality subgroups were at a similar risk compared to the general population. CONCLUSION Our study corroborated the known association between these tumors and found a 26% risk of meningioma development in women with breast cancer, with younger patients and those with a more aggressive disease having a higher than expected risk.