LAUSR

Diffuse intrinsic pontine glioma (DIPG) with H3 K27M mutation is a rare brain tumor that primarily affects children. It is extremely lethal, and our understanding of the natural course of this disease, and how it progresses, is lacking. We herein present a case that demonstrates how aggressive this disease can be following progression, with remarkable spread throughout the brain and spine despite upfront treatment by radiation therapy. Although rarely reported, widespread dissemination of metastatic DIPG throughout the brain and spine is possible.