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PURPOSE It remained controversial that whether patients with atypical meningiomas can benefit from postoperative radiotherapy (PORT) after gross total resection (GTR). This study aimed to explore the effectiveness of PORT on atypical meningioma patients after GTR based on our single-center data with a relatively large sample size. METHODS Patients with atypical meningioma who underwent GTR in our center were reviewed. Univariable and multivariable Cox proportional-hazard models were conducted for survival analyses. The Kaplan-Meier survival curves were generated, and the 5-year progression-free survival (PFS) rates were calculated. RESULTS A total of 260 patients were enrolled in this study. PORT was not associated with PFS (p = 0.507). Gender (p = 0.006, HR [95% CI] = 0.418 [0.224 - 0.781]), age (p = 0.032, HR [95% CI] = 1.032 [1.003 - 1.061) and tumor location (p = 0.026, HR [95% CI] = 0.199 [0.048 - 0.824]) were independent predictors for PFS. The 5-year PFS rates of patients receiving PORT (85.6%) were similar to those not receiving PORT (84.8%). The 5-year PFS rate was 100% in the patients with convexity atypical meningiomas regardless of receiving PORT or not. CONCLUSION PORT may not prolong PFS in patients with atypical meningiomas after GTR. Patients with convexity atypical meningiomas had favorable outcome after GTR, regardless of PORT.