LAUSR

Extracellular vesicles might be originated from different kinds of cells, mediating cell-cell communication in different normal and pathological contexts. These vesicles contain several biomolecules among them are microRNAs (miRNAs). These small regulatory transcripts can influence cell differentiation, proliferation and migration. Their inclusion in the stem cell-derived microvesicles has provided them the capacity to mediate a number of functional effects of stem cells on normal or malignant cells. In the present manuscript, we explain the results of studies which evaluated the miRNA profile of stem cell-originated extracellular vesicles and their impacts on surrounding cells in normal and tumoral microenvironments. The presented data in the current review shows that exosome-derived miRNAs have practical significance in at least two fields of biology, i.e. regenerative medicine and cancer treatment.