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Distinguishing between expert and statistical systems for application under ICH M7

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Graphical abstract Figure. No Caption available. HighlightsDefining characteristics of expert and statistical in silico systems are presented.Mechanisms to ensure both systems complement each other are described.Risks of in silico models… Click to show full abstract

Graphical abstract Figure. No Caption available. HighlightsDefining characteristics of expert and statistical in silico systems are presented.Mechanisms to ensure both systems complement each other are described.Risks of in silico models that may be inappropriate for ICH M7 are highlighted.

Keywords: statistical systems; expert statistical; distinguishing expert; systems application; application ich; toxicology

Journal Title: Regulatory Toxicology and Pharmacology
Year Published: 2017

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