Graphical abstract Figure. No Caption available. HighlightsDefining characteristics of expert and statistical in silico systems are presented.Mechanisms to ensure both systems complement each other are described.Risks of in silico models… Click to show full abstract
Graphical abstract Figure. No Caption available. HighlightsDefining characteristics of expert and statistical in silico systems are presented.Mechanisms to ensure both systems complement each other are described.Risks of in silico models that may be inappropriate for ICH M7 are highlighted.
               
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