LAUSR

ABSTRACT The aryloxyalkanoate dioxygenase‐12 (AAD‐12) protein is expressed in genetically modified soybean events DAS‐68416‐4 and DAS‐444ϕ6‐6. Expression of the AAD‐12 protein in soybeans confers tolerance to the herbicide 2,4‐dichlorophenoxyacetic acid (2,4‐D) providing an additional herbicide choice to farmers. This enzyme acts by catalyzing the degradation of 2,4‐D into herbicidally inactive metabolites. To meet evolving interpretation of regulations in the European Union, three separate 28‐day repeat‐dose oral mouse studies were conducted at increasing doses of up to 1100 mg AAD‐12 protein/kg bw/day. No treatment‐related effects were seen in any of these three studies. HighlightsThe AAD‐12 protein is expressed in genetically modified soybeans.AAD‐12 confers herbicidal tolerance to 2,4‐D.No treatment‐related effects of AAD‐12 protein in three 28‐day mouse studies.