LAUSR

Objectives: Frailty is a measure of decreased physiologic reserve that has been associated with inferior clinical outcomes among surgical patients. We assessed these findings among patients undergoing surgery for cervical cancer (CC) in a national database. Methods: Patients undergoing inpatient gynecological surgery to treat CC were identified using the 2005-2017 National Inpatient Sample database. International Classification of Diseases-9th and -10th Revision (ICD-9 and ICD-10) codes were used in conjunction with the Johns Hopkins Adjusted Clinical Groups (ACG) frailty-defining diagnosis indicator to designate frailty. Multivariate regression models were used to assess the association of frailty with clinical outcomes. Results: Of an estimated 53,458 surgical patients with CC, 2.5% (1,316) were defined as frail. Frail patients were older (55 vs 49 years; p Download : Download high-res image (57KB) Download : Download full-size image Conclusions: Frailty is independently associated with worse outcomes and increased resource use among patients undergoing surgery for CC. Though the incidence of CC patients undergoing surgery decreased over the study period, both the incidence and proportion of frail patients significantly increased. Despite more patients being frail, the rate of mortality did not change over time. Efforts to further mitigate the impact of frailty should be explored in this patient population.