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(p = 0.052) for 1–29 g/day, 3.2 (p = 0.003) for 30–49 g/day, 3.51 (p < 0.0001) for 50–99 g/day and 5.61 (p < 0.0001) for ≥100 g/day. The baseline… Click to show full abstract
(p = 0.052) for 1–29 g/day, 3.2 (p = 0.003) for 30–49 g/day, 3.51 (p < 0.0001) for 50–99 g/day and 5.61 (p < 0.0001) for ≥100 g/day. The baseline MELD score was not predictive of long-term outcomewhile Lille score (p = 0.02) and alcohol relapse (p < 0.0001) were independent prognostic factors. Conclusions: This study shows that new therapeutic development for severe AH must target liver injury for short term and alcohol consumption for long term. Thus, health agencies can endorse future study design adapted to the time-frame of factors influencing mortality. With this in mind, drugs targeting mechanisms involved in liver injury should only be tested for the short-term period.
Journal Title: Journal of Hepatology
Year Published: 2017
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