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Retreatment with Direct Active Antivirals of genotype 1, 3 and 4 chronic hepatitis C patients who previously failed an anti-NS5A-containing regimen in real world

Recent guidelines recommend that patients who failed DAAs treatment with nonstructural protein 5A inhibitors (NS5A) should be retreated 24 weeks with Sofosbuvir (SOF) combined with either a protease inhibitor for… Click to show full abstract

Recent guidelines recommend that patients who failed DAAs treatment with nonstructural protein 5A inhibitors (NS5A) should be retreated 24 weeks with Sofosbuvir (SOF) combined with either a protease inhibitor for those with NS5A RAVs, or with a NS5A inhibitor for those without NS5A RAVs (1, 6, 7). Little is known on real life retreatment of patients who had failed to achieve sustained virological response (SVR) on previous NS5A-based therapy (1).

Keywords: active antivirals; antivirals genotype; genotype chronic; retreatment; direct active; retreatment direct

Journal Title: Journal of Hepatology
Year Published: 2017

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