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Background: In the failing heart there is impaired protein turnover and an accumulation of ubiquitinated proteins within cardiomyocytes. This accumulation, which likely has detrimental effects on myocyte function, has been… Click to show full abstract
Background: In the failing heart there is impaired protein turnover and an accumulation of ubiquitinated proteins within cardiomyocytes. This accumulation, which likely has detrimental effects on myocyte function, has been attributed to proteasome dysfunction. However, the extent to which changes in
Keywords:
heart;
ubiquitinated proteins;
accumulation ubiquitinated;
autophagic flux;
impaired autophagic;
flux contributes
Journal Title: Journal of the American College of Cardiology
Year Published: 2017
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Journal Title: Journal of the American College of Cardiology
Year Published: 2017
Link to full text (if available)
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recommendations!