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Background: Bempedoic acid is a novel oral agent that reduces hepatic cholesterol synthesis by inhibiting ATP-citrate lyase (ACL) leading to upregulation of the LDL receptor and a reduction in plasma… Click to show full abstract
Background: Bempedoic acid is a novel oral agent that reduces hepatic cholesterol synthesis by inhibiting ATP-citrate lyase (ACL) leading to upregulation of the LDL receptor and a reduction in plasma low-density lipoprotein cholesterol (LDL-C). Although this mechanism of action is similar to that of
Keywords:
citrate lyase;
atp citrate;
target validation;
genetic target
Journal Title: Journal of the American College of Cardiology
Year Published: 2017
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Journal Title: Journal of the American College of Cardiology
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!