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THE ROLE OF MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF METALLOPROTEINASES IN DUCHENNE MUSCULAR DYSTROPHY CARDIOMYOPATHY

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Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Better understanding of molecular pathways leading to DMD fibrosis may provide novel targets for drug therapy. Matrix metalloproteinases… Click to show full abstract

Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Better understanding of molecular pathways leading to DMD fibrosis may provide novel targets for drug therapy. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate collagen

Keywords: muscular dystrophy; tissue inhibitors; inhibitors metalloproteinases; duchenne muscular; matrix metalloproteinases

Journal Title: Journal of the American College of Cardiology
Year Published: 2018

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