In cardiac and skeletal muscle, alpha-actinins are critical cytoskeletal proteins that anchor actin filaments within the sarcomere. Mutations in ACTN2 have been associated with cardiac abnormalities, including arrhythmias, hypertrophic and… Click to show full abstract
In cardiac and skeletal muscle, alpha-actinins are critical cytoskeletal proteins that anchor actin filaments within the sarcomere. Mutations in ACTN2 have been associated with cardiac abnormalities, including arrhythmias, hypertrophic and dilated cardiomyopathies. However, the mechanisms behind how
               
Click one of the above tabs to view related content.