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TARGETED METABOLOMICS IDENTIFIES ELEVATED SEROTONIN LEVELS IN CARRIERS OF A TCF7L2 DIABETES-RISK ALLELE

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The transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Its polymorphism rs7903146 is associated with risk for metabolic diseases, primarily diabetes, whereas the molecular mechanisms explaining… Click to show full abstract

The transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Its polymorphism rs7903146 is associated with risk for metabolic diseases, primarily diabetes, whereas the molecular mechanisms explaining how TCF7L2 impacts metabolism have remained unsolved. We evaluated the

Keywords: elevated serotonin; levels carriers; metabolomics identifies; serotonin levels; identifies elevated; targeted metabolomics

Journal Title: Journal of the American College of Cardiology
Year Published: 2019

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