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MYOSIN LIGHT CHAIN DEPHOSPHORYLATION BY PPP1R12C PROMOTES ATRIAL HYPOCONTRACTILITY IN ATRIAL FIBRILLATION

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Atrial fibrillation (AF) increases stroke risk five-fold. Atrial hypocontractility from atrial myosin light chain (MLC2a) dephosphorylation contributes to stroke risk in AF. Recent proteomic data has shown increased protein phosphatase… Click to show full abstract

Atrial fibrillation (AF) increases stroke risk five-fold. Atrial hypocontractility from atrial myosin light chain (MLC2a) dephosphorylation contributes to stroke risk in AF. Recent proteomic data has shown increased protein phosphatase 1 subunit 12C (PPP1R12C) targeting to MLC2a in AF. However, it

Keywords: atrial fibrillation; atrial hypocontractility; myosin light; hypocontractility atrial; light chain

Journal Title: Journal of the American College of Cardiology
Year Published: 2020

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