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A COMPOSITE METRIC TO IDENTIFY HFPEF PATIENTS LIKELY TO BENEFIT FROM SPIRONOLACTONE

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The TOPCAT trial, overall, showed no benefit for spironolactone in heart failure patients with preserved ejection fraction (HFpEF). Post-hoc, spironolactone helped participants from the Americas but not Eastern Europe, potentially… Click to show full abstract

The TOPCAT trial, overall, showed no benefit for spironolactone in heart failure patients with preserved ejection fraction (HFpEF). Post-hoc, spironolactone helped participants from the Americas but not Eastern Europe, potentially due to differences in baseline characteristics or adherence. We

Keywords: identify hfpef; composite metric; hfpef patients; benefit spironolactone; hfpef; metric identify

Journal Title: Journal of the American College of Cardiology
Year Published: 2020

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