The TOPCAT trial, overall, showed no benefit for spironolactone in heart failure patients with preserved ejection fraction (HFpEF). Post-hoc, spironolactone helped participants from the Americas but not Eastern Europe, potentially… Click to show full abstract
The TOPCAT trial, overall, showed no benefit for spironolactone in heart failure patients with preserved ejection fraction (HFpEF). Post-hoc, spironolactone helped participants from the Americas but not Eastern Europe, potentially due to differences in baseline characteristics or adherence. We
               
Click one of the above tabs to view related content.