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Background: Inducible heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, carbon monoxide and ferrous iron. These HO-1 products have potent antioxidant, vasodilatory and anti-inflammatory actions. Expression of HO-1… Click to show full abstract
Background: Inducible heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, carbon monoxide and ferrous iron. These HO-1 products have potent antioxidant, vasodilatory and anti-inflammatory actions. Expression of HO-1 has been linked to nitric oxide (NO) bioavailability, a process influenced by the omega-3 fatty acid (ω-3) eicosapentaenoic acid (EPA). Unlike trials using mixed ω-3 formulations containing docosahexaenoic acid (DHA), EPA only treatment (icosapent ethyl) was associated with reduced cardiovascular (CV) events in REDUCE-IT.
Journal Title: Journal of the American College of Cardiology
Year Published: 2021
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