LAUSR

Abstract Protopanaxadiol (PPD) has inhibitory effects on a variety of tumor cells, but the poor water solubility and low availability limit its clinical application. By using polyethylene glycol (PEG)-modified hollow gold nanoparticles (HAuNs-PEG) as the transport carriers, we prepared here the PPD-loaded HAuNs-PEG (HAuNs-PEG-PPD). And then we conducted a number of experiments to investigate the in vitro anti-laryngeal cancer effect (Hep-2 cell as a model) of HAuNs-PEG-PPD, such as using high performance liquid chromatography (HPLC) to detect the sustained release effect, MTT assay to detect the inhibitory effect on the proliferation of Hep-2 cells, and flow cytometry to determine the apoptosis of Hep-2 cells. The results showed that HAuNs-PEG-PPD had an obvious sustained release effect. Compared with those in the control group, HAuNs-PEG group and PPD group, the survival rate of Hep-2 cells decreased and the apoptosis rate increased significantly (p