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Constitutively expression of the pathway-specific activators is an effective method to activate silent gene clusters and improve natural product production. In this study, nine shunt products of aminoansamycins (1-9) were… Click to show full abstract
Constitutively expression of the pathway-specific activators is an effective method to activate silent gene clusters and improve natural product production. In this study, nine shunt products of aminoansamycins (1-9) were identified from a recombinant mutant strain S35-LAL by overexpressed the large-ATP-binding regulator of the LuxR family (LAL) gene aas1 in Streptomyces sp. S35. All the compounds showed no anti-microbial, anti-T3SS and cytotoxic activities.
Keywords:
streptomyces s35;
products aminoansamycins;
mutant strain;
shunt products
Journal Title: Chinese journal of natural medicines
Year Published: 2020
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Journal Title: Chinese journal of natural medicines
Year Published: 2020
Link to full text (if available)
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recommendations!