LAUSR

The mechanism of treating COVID-19 with traditional Chinese medicine and monomers based on ACE2 receptor is investigated Traditional Chinese medicine and monomers acting on angiotensin converting enzyme II (ACE2) receptor was retrieved by TCMSP database UniProt, GeneCards and other databases were used to query the gene names corresponding to the target of Chinese medicine monomer, and then Cytoscape 3 2 1 was used to construct the compound-target (gene) network DAVID was used to carry out the gene ontol (GO) functional enrichment anal and KEGG pathway enrichment anal based on the Kyoto encyclopedia of genes and genomes to predict its mechanism of action There were 54 targets in the network, including AKT1, VEGFA and TNF GO function enrichment anal revealed 554 GO items (P <0 05) including 486 biol process (BP) items, 26 cell component (CC) items, and 42 mol function (MF) items There were 162 signaling pathways (P <0 05) involved in small cell lung cancer, non-small cell lung cancer, renin-angiotensin system pathway, etc The results of mol docking showed that the affinity of puerarin with ACE2 and SARS-CoV-2 was similar to the recommended drugs Puerarin may regulate multiple signaling pathways by binding ACE2 to AGTR1, NOS3, HIF1A and other targets, which may have therapeutic effects on COVID-19