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Spectrum scores: Toward a better definition of de-escalation.

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Abstract Spectrum scores measure antimicrobial utilization while also quantifying the spectrum of activity. Accordingly, changes in spectrum score can be used to identify antimicrobial de-escalation. We show that spectrum-score–based de-escalation… Click to show full abstract

Abstract Spectrum scores measure antimicrobial utilization while also quantifying the spectrum of activity. Accordingly, changes in spectrum score can be used to identify antimicrobial de-escalation. We show that spectrum-score–based de-escalation has a 95.7% positive percentage agreement and 81.6% negative percentage agreement versus de-escalation defined as stopping either antistaphylococcal or antipseudomonal agents.

Keywords: toward better; escalation; better definition; spectrum; spectrum scores; scores toward

Journal Title: Infection control and hospital epidemiology
Year Published: 2022

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