LAUSR

OBJECTIVE To model the effects of active detection and isolation (ADI) regarding Clostridioides difficile infection (CDI) in the bone marrow transplant (BMT) unit of our hospital. SETTING ADI was implemented in a 21-patient bone marrow unit. PATIENTS Patients were bone marrow recipients on this unit. INTERVENTIONS We compared active ADI, in which patients who tested positive for colonization of C. difficile before their hospital stay were placed under extra contact precautions, with cases not under ADI. RESULTS Within the BMT unit, ADI reduced total cases of CDI by 24.5% per year and reduced hospital-acquired cases by ∼84%. The results from our simulations also suggest that ADI can save ∼$67,600 per year in healthcare costs. CONCLUSIONS Institutions with active BMT units should consider implementing ADI.