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Brain-wide synaptic wiring diagrams will be necessary to accurately predict brain-wide circuit computations underlying the diverse behaviors produced by an organism. Currently only volume electron microscopy (VEM) provides the nanometer-scale… Click to show full abstract
Brain-wide synaptic wiring diagrams will be necessary to accurately predict brain-wide circuit computations underlying the diverse behaviors produced by an organism. Currently only volume electron microscopy (VEM) provides the nanometer-scale resolution required to reliably and precisely reconstruct arbitrary neuronal circuits contained within the imaged volume. Given that VEM datasets for large volumes may exceed petabytes, the automation of high-throughput VEM is critical for scaling up to mammalian whole-brains, such as the mouse or Etruscan pygmy shrew [1].
Journal Title: Microscopy and Microanalysis
Year Published: 2017
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